Biochemistry

Amy Frary, Chair

Dina Bevivino, Academic Department Coordinator


G04 Carr Laboratory
413-538-2214
https://www.mtholyoke.edu/acad/biochemistry

Overview and Contact Information

The major in biochemistry is intended to provide a strong background in the fundamentals of both biology and chemistry and to develop an awareness of the unique principles of biochemistry.

Biochemistry is the study of reactions that underpin the living system. These include the vital metabolic reactions that provide cells with energy to perform myriad activities and functions, and the biosynthetic reactions that enable cells to renew, repair, grow, and divide. The linkage of biochemistry with molecular biology for the past 30 years has brought revolutionary advances in our understanding of the living world, the human organism, disease etiology, and medicine.

The interdisciplinary major in biochemistry offers a rigorous course of study that builds on two years of fundamental course work in biology and chemistry. With this broad preparation, students engage with biochemistry and molecular biology at a very high level, allowing them to integrate their knowledge in molecular and cellular biology, and to think and address issues occurring at the forefront of the biochemical/biomedical sciences. Majors are also encouraged to participate in academic-year and/or summer research and majors usually have more than one research internship experience before graduation.

See Also

Faculty

This area of study is administered by the Biochemistry Committee:

Amy Frary, Professor of Biological Sciences

Craig Woodard, Christianna Smith Professor of Biological Sciences, Teaching Spring Only

Alan Van Giessen, Associate Professor of Chemistry

Jason Andras, Assistant Professor of Biological Sciences

Katie Berry, Clare Boothe Luce Assistant Professor of Biochemistry

Kyle Broaders, Assistant Professor of Chemistry, On Leave 2017-2018

Amy Camp, Assistant Professor of Biological Sciences

Kathryn McMenimen, Assistant Professor of Chemistry

Requirements for the Major

A minimum of 48 credits: 

CHEM-101General Chemistry I4
or CHEM-160 Integrated Introduction to Biology and Chemistry
CHEM-201General Chemistry II4
CHEM-202Organic Chemistry I4
CHEM-302Organic Chemistry II4
As a prerequisite for CHEM-308 or CHEM-346:
Calculus II
Force, Motion, and Energy
CHEM-346Physical Chemistry of Biochemical Systems With Lab4
or CHEM-308 Chemical Thermodynamics with Lab
BIOL-145Introductory Biology 24
or BIOL-160 Integrated Introduction to Biology and Chemistry
BIOL-200Introductory Biology II: How Organisms Develop4
BIOL-230Cell and Molecular Biology4
BIOCH-311Protein Biochemistry and Cellular Metabolism4
BIOCH-314Nucleic Acids Biochemistry and Molecular Biology4
8 additional credits elected from 300-level courses in biochemistry, biology, or chemistry 18
Total Credits48
1

This requirement is intended to increase the breadth and depth of your knowledge and application of biochemistry through related 300-level course work.

2

 Students may select any BIOL-145 topic, such as BIOL-145ABBIOL-145BNBIOL-145GW and BIOL-145RG.

Other Requirements

  • Senior Symposium. All seniors must give an oral presentation on a biochemical topic in the Senior Symposium.

Additional Specifications

  • Students who are interested in taking the biochemistry core courses (BIOCH-311 and BIOCH-314) in their junior year are encouraged to complete at least CHEM-101 (or CHEM-160) and CHEM-201 and BIOL-145 (or BIOL-160) and BIOL-200 during the first year.
  • The committee further recommends CHEM-325 to students planning graduate work in biochemistry.
  • Independent study 295 or 395 does not count towards the minimum of 48 required credits.
  • A student coming to the College with advanced credits from IB or A-level course work or Advanced Placement examinations, in accordance with the number of advanced credits she has received, can skip up to four courses at the introductory level: BIOL-145 (or BIOL-160), BIOL-200; CHEM-101 (or CHEM-160), CHEM-201.  However, advanced placement courses cannot replace more than 8 credits of the major. A student considering skipping introductory-level courses should consult with the program chair or other members of the Biochemistry Program Committee.

Course Offerings

BIOCH-295 Independent Study

Fall and Spring. Credits: 1 - 4

Independent work in biochemistry can be conducted with any member of the biochemistry committee and, upon approval, also with other members of the biological sciences and chemistry departments and program in neuroscience and behavior.

The department
Instructor permission required.
Notes: Students conducting an independent lab research project for credit in a department, program, or lab covered by the College's chemical hygiene plan must participate in a safety training session before beginning research.

BIOCH-311 Protein Biochemistry and Cellular Metabolism

Fall. Credits: 4

This course is a rigorous introduction to the study of protein molecules and their role as catalysts in the cell. Topics include general principles of protein folding, protein structure-function correlation, enzyme kinetics and mechanism, carbohydrate and lipid biochemistry, and metabolic pathways (catabolic and anabolic) and their interaction and cross-regulation. Biological transformation of energy is considered in light of the principles of thermodynamics.

Crosslisted as: BIOL-311, CHEM-311
Applies to requirement(s): Math Sciences
K. Berry
Restrictions: This course is limited to Biochemistry majors only.
Prereq: BIOL-230 (or BIOL-210) and CHEM-302. Coreq: BIOCH-311L.

BIOCH-314 Nucleic Acids Biochemistry and Molecular Biology

Spring. Credits: 4

This course is an in-depth examination of DNA and RNA structures and how these structures support their respective functions during replication, transcription, and translation of the genetic material. Emphasis is on the detailed mechanisms associated with each step of gene expression. Discussions incorporate many recent advances brought about by recombinant DNA technology.

Crosslisted as: BIOL-314, CHEM-314
Applies to requirement(s): Math Sciences
K. Berry
Restrictions: This course is limited to Biochemistry majors only.
Prereq: BIOCH-311. Coreq: BIOCH-314L.

BIOCH-330 Topics in Biochemistry and Molecular Biology

This course each year examines a number of important and exciting topics in biochemistry, molecular biology, and other related fields of biology. The intellectual and research development that formulated these fundamental concepts is traced through extensive readings of the primary literature. Discussions emphasize the critical evaluation of experimental techniques, data analysis, and interpretation. This is a seminar-style course in which students will bear responsibility for the synthesis and presentation of assigned papers; substantial student participation in the form of oral presentation is expected.

BIOCH-330MB Topics in Biochemistry and Molecular Biology

Not Scheduled for This Year. Credits: 4

This course each year examines a number of important and exciting topics in biochemistry, molecular biology, and other related fields of biology. The intellectual and research development that formulated these fundamental concepts is traced through extensive readings of the primary literature. Discussions emphasize the critical evaluation of experimental techniques, data analysis, and interpretation. Substantial student participation in the form of oral presentation is expected. This course will focus on antibiotic resistance and the emergence of drug-resistant bacteria.

Applies to requirement(s): Meets No Distribution Requirement
K. McMenimen
Prereq: CHEM-212 and either BIOCH-311 or BIOCH-314.

BIOCH-330RN Topics in Biochemistry and Molecular Biology: 'The RNA World: The Origin of Life to Modern Cells'

Spring. Credits: 4

RNA is believed by many to have been the first macromolecule to evolve. In a hypothesized "RNA world," RNA would have simultaneously served the roles of carrying genetic information and catalyzing chemical reactions within early cells. The past three decades have been a renaissance for RNA biology, as researchers have uncovered the critical role RNA plays in eukaryotic and bacterial gene regulation and defense, as well as the potential for RNAs to perform catalysis. This seminar will introduce students to modern approaches to study the structure and function of RNA and will explore the chemical and biological roles RNA plays in modern cells as well as its role in the origin of life.

Applies to requirement(s): Math Sciences
Other Attribute(s): Speaking-Intensive
K. Berry
Prereq: BIOCH-311, or BIOCH-314, or CHEM-212.

BIOCH-395 Independent Study

Fall and Spring. Credits: 1 - 8

Independent work in biochemistry can be conducted with any member of the biochemistry committee and, upon approval, also with other members of the biological sciences and chemistry departments and program in neuroscience and behavior.

The department
Instructor permission required.
Notes: See safety training restrictions in the course description for Biochemistry 295